Ive been using the OISD list for myself and family members for the past couple of years without issues. It’s specifically made to to be unnoticeable, by whitelisting hosts that would cause issues.
One thing to note is that it’s not a full replacement for adblockers, as DNS blockers can only block full hosts and not all ads and tracking are served from dedicated hostnames. Things like YouTube ads will be unaffected by DNS based blocking. It does really make a difference, though, including for apps with banners.




By default Tailscale devices prefer the local DNS server for any hostname that’s not part of your Tailscale network, unless you’ve configured a global DNS server. There’s also the option to configure split DNS and have a different DNS server for certain domains (for example your own domain). You can also add search domains to allow short hostnames to be resolved to FQDNs of your choice.